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Jerome Charmet

Blood coagulation is critically important to maintain health during trauma or surgery and it also plays a central role to diseases such as heart attack, strokes and haemophilia. My PhD aims at developing a biosensor for point-of-care (POC) diagnosis to monitor blood coagulation. Such a sensor would enable a rapid intervention in cases of traumatic injuries; provide real-time monitoring during surgery and a low cost diagnosis biosensor for other diseases. Thromboelastography is considered to be the most informative blood coagulation monitoring method and provides a graphic representation of clot formation and subsequent lysis. However, its operation in the non-linear viscoelastic regime, that delays clot formation, and its multiple daily calibrations make it a poor candidate for POC diagnosis. Preliminary results show that micro-electro-mechanical system (MEMS) based devices can be adapted for this purpose. For my PhD, I am designing a novel high-resolution MEMS device to monitor the entire blood coagulation process. My research also addresses fundamentals underlying the operation of such devices under liquid environments and evaluating the role of physico-chemical properties of the surface on device response.